The second part of City Slickers begins after the death of Curly. It is the 40th birthday of Mitch Robbins and the day begins quite good until he returns home (after a hard day at the radio station) and finds his brother Glen, the black sheep of the family, in his sofa. Nevertheless he is about to have a wonderful birthday-night with his wife when he discovers a treasure map of Curly by chance. Together with Phil (from the first part) and unfortunately with Glen he tries to find the hidden gold...

Two jilted lovers spend fifteen years of marriage together, only to find that they might no longer love each other. In this time they have two children and go through the various (dramatic and comical) events that take place in an average marriage.